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Large granular lymphocytic leukaemia (LGLL)

Large granular lymphocytic leukaemia (LGLL) is a very rare, specific type of leukaemia. LGLL occurs in two forms but these behave the same way and are treated the same way so they are not described separately.

Blood cells are formed in the bone marrow, which is the spongy tissue found inside the bones. Blood-forming stem cells divide to produce either more stem cells or immature cells that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.

Large granular lymphocytic leukaemia (LGLL) affects T lymphocytes or, less commonly, NK lymphocytes. 

  • Published: Aug 2016
  • Next planned review: Aug 2018